bioRxiv. Enrichment of sequencing targets from the human genome by solution hybridization. Twist Bioscience is a public biotechnology company based in South San Francisco that manufactures synthetic DNA and DNA products for customers in a wide range of industries. Ginkgos main offices occupy a converted warehouse in Bostons seaport district. Gurney A, Axelrod F, Bond CJ, Cain J, Chartier C, Donigan L, Fischer M, Chaudhari A, Ji M, Kapoun AM, Lam A, Lazetic S, Ma S, Mitra S, Park IK, Pickell K, Sato A, Satyal S, Stroud M, Tran H, Yen WC, Lewicki J, Hoey T. Proc Natl Acad Sci U S A. Before that, he spent nine years at Celgene as the lead West Coast attorney supervising over 100 business transactions, including in- and out- licenses, options, collaborations and M&A agreements, and held primary legal responsibility for Celgenes alliances, equity investments and big data machine learning initiative. The second phase, just underway, is about writing genes. PubMed PMID: 24233382. Hum Immunol. MAbs. Targeted and genome-scale strategies reveal gene-body methylation signatures in human cells. Sato AK, Sexton DJ, Morganelli LA, Cohen EH, Wu QL, Conley GP, Streltsova Z, Lee SW, Devlin M, DeOliveira DB, Enright J, Kent RB, Wescott CR, Ransohoff TC, Ley AC, Ladner RC. PubMed PMID: 25511917; PubMed Central PMCID: PMC4596908. They have really changed our lives for the better. On that same day, Twist and Leproust filed a cross-complaint, asserting six new and Ph.D. in chemical engineering from the University of Michigan, Ann Arbor where she studied the intersection of genetics, miniaturization, and dynamics of complex fluids. 2002 Jan;29(1):107-13. Researchers can now design and mass-produce genetic material a technique that helped build the mRNA vaccines. We passed one machine that uses microfluidics technology to mix reagents and cells and another that uses mass spectrometry to rapidly analyze the chemical composition of liquids. 2008 April: 20-33. Emily Leproust is an early pioneer in the synthesis and sequencing of DNA. Subscribe to my weekly newsletters in synthetic biology. Antib Ther. Another way to cultivate culture is driven by how you act when there is a failure. At the time, DNA synthesis was a slow and difficult process. Epub 2012 Jul 2. in chemical engineering from the Indian Institute of Technology, New Delhi and an M.S. Epub 2015 Apr 18.PubMed PMID: 25826247. This investment - Seed Round - Cradle - was valued at 5.5M. Prior to Televerde, heserved as interim CFO of several public and private companies including Enercore, NextAutoworks, Fisker Automotive and Numonyx (acquired by Micron). She was the human resources manager for Operon Technologies (acquired by QIAGEN) where her responsibilities included creating strategy, overseeing benefits for all employees, and delivering training, recruitment and retention programs. Nonlinear-optical effects in ion-exchanged semiconductor-doped glass waveguides. Emily Leproust Net Worth The estimated Net Worth of Emily M. Leproust is at least $71.4 Million dollars as of 18 January 2022. A conformational change in the human major histocompatibility complex protein HLA-DR1 induced by peptide binding. This interview was conducted by Rebecca Coons, Executive Editor of Industrial Biotechnology, and published in the same journal (Leproust E, Industrial Biotech 2021;17:107108, https://www.liebertpub.com/doi/full/10.1089/ind.2021.29253.ele ). Effects of atmospheric ozone on microarray data quality. PMCID: PMC7454256. This will be important for doctors to be able to distinguish between Covid-19 and other seasonal viruses. 2003 71(3) 316. I have people coming to me saying something is way too hard. Picosecond nonlinear polarization switching with a fiber filter. GOOGL Leproust: Twist is my best achievement. Bioconjug Chem. [8] She worked for the company Agilent where she was Director of Applications and Chemistry R&DGenomics before starting the company Twist Bioscience. On this Wikipedia the language links are at the top of the page across from the article title. You could have a better material to get the packaging we need as consumers. Dr. Leproust holds the position of Chairman, President & Chief Executive Officer for Twist Bioscience Corp. She is also on the board of CM Life Sciences, Inc. Dr. Leproust previously was Chairman at Nektar Therapeutics and Director-Applications . 2015 Nov;32(11):3480-93. doi:10.1007/s11095-014-1596-8. Kapoor N, Vanjak I, Rozzelle J, Berges A, Chan W, Yin G, Tran C, Sato AK, Steiner AR, Pham TP, Birkett AJ, Long CA, Fairman J, Miura K. Malaria Biochemistry. 2022 Jan-Dec;14(1):2002236. doi: 10.1080/19420862.2021.2002236. Santambrogio L, Sato AK, Fischer FR, Dorf ME, Stern LJ. Almost as soon as the Chinese C.D.C. We always tell the team: if it was easy, everybody would be doing it. PubMed PMID: 29861435. 1999 May 4;38(18):5878-87. Antibodies, which many experts believe are among the most promising drug molecules, require custom DNA blueprints to be made. PubMed PMID: 10626736. Observation of ultrafast nonlinear polarization switching induced by polarization instability in a birefringent fiber rocking filter. The reagents those famous bases (As, Ts, Cs and Gs) that make up DNA were pipetted onto a plastic plate with 96 pits, or wells, each of which held roughly 50 microliters, equivalent to one eyedropper drop of liquid. Did we run into bacteria that are now so difficult to kill that the new ones we find dont really work on them? Whatever the reason, the reality is that weve been running out of new antibiotics in the face of growing antibiotic resistance. He attended MIT, earning a Ph.D. in biological chemistry while studying the immune system. Aug 16, 2022 Updated Aug 16, 2022, 2:43pm PDT Listening to Emily Leproust speak, the feeling is sometimes reminiscent of a gruff football coach rather than CEO of a fast-growing biotech. If you create a culture where failure is not an option, people always play it safe. It is now possible to take our understanding of molecular biology how DNA specifies the sequence of RNA, which in turn specifies the production of proteins and use Crispr and DNA synthesis to devise genetic recipes that produce the outputs we want. Substitution of aspartic acid at beta57 with alanine alters MHC class II peptide binding activity but not protein stability: HLA-DQ (alpha1*0201, beta1*0302) and (alpha1*0201, beta1*0303). Scalable gene synthesis by selective amplification of DNA pools from high-fidelity microchips. Called oligos, they can then be joined together to form genes. A flexible light-directed DNA chip synthesis gated by deprotection using solution photogenerated acids. Twist has put its antibody expertise to work in a comprehensive way, making several new research products available to the community. Epub 2006 Oct 17. Review. If the first phase of the genomics revolution focused on reading genes through gene sequencing, the second phase is about writing genes. But on Wednesday, Leproust's former employer, Agilent, filed a lawsuit claiming that . This article about an American scientist is a stub. Twist also is part of the $5 million XPRIZE Rapid Covid Testing competition to accelerate the development of high-quality Covid-19 testing that is low cost, easy to use, and fast-turnaround, enabling frequent testing. Tom Z.Yuan,CarolinaLucas,Valter S.Monteiro,AkikoIwasaki,Marisa L.Yang,Hector F.Nepita,Ana G.Lujan Hernandez,Joseph M.Taft,LesterFrei,Sai T.Reddy,Cdric R.Weber,Kevin P.Malobisky,RodrigoMesquita,Aaron K.Sato. Multiplex amplification of large sets of human exons. PubMed PMID: 28596531; PubMed Central PMCID: PMC5465077. His expertise includes driving product roadmap leadership and establishing strategic relationships with ecosystem stakeholders to fuel the adoption of DNA data storage solutions across existing and emerging archive storage use cases. Tracey initially served as Abveris chief operating officer where she managed operations and project development for both therapeutic and critical reagent in vivo antibody discovery campaigns. , Amazon GEN Genetic Engineering and Biotechnology News, Teamwork and Twist: A Conversation with CEO Emily Leproust, Molecular Structure Analysis and Quantification Tool Introduced for At-Line Biomanufacturing, Nanoparticles Rapidly Crystallize Proteins, Speed Up Purification, Alzheimers Model Mice Treated Using Targeted Protein Degradation, Digital Twins Illuminate a Path to Personalized Inflammatory Disease Treatment, Research Institute Focuses on Continuous Manufacturing of Advanced Therapies, Cell Therapy Sector Addresses Issue of Production Technology as Stumbling Block, https://www.liebertpub.com/doi/full/10.1089/ind.2021.29253.ele, Mastering the Microbiome: Treating Disease with Bacteria, Monoclonal Antibody Prevents Malaria in First-in-Human Clinical Trial, Search and Replace: Andrew Anzalone Details How Genome Editing Went Prime Time on Close to the Edge, Molecular Assemblies Is Enzymatically Synthesizing the Next Generation of DNA Products, Genomic Search and Replace Swaps Out Seven Codons. Become a TED Member to help us inspire millions of minds with powerful ideas. Its good, but there is a lot more we can do. Emily Leproust is an American scientist and entrepreneur. Can you talk about your experience as a woman in STEM and how we can improve diversity in science? PubMed PMID: 24517929; PubMed Central PMCID: PMC4011911. Biography of Emily Leproust. Angel Defining variant-resistant epitopes targeted by SARS-CoV-2 antibodies: A global consortium study. Use of peptide phage display in therapeutics, diagnostics, and affinity separations. Epub 2014 Jan 29. I then went to work in a very big company (Agilent) in R&D for 13 years and moved up the chain. Yen WC, Fischer MM, Axelrod F, Bond C, Cain J, Cancilla B, Henner WR, Meisner R, Sato A, Shah J, Tang T, Wallace B, Wang M, Zhang C, Kapoun AM, Lewicki J, Gurney A, Hoey T. Clin Cancer Res. Prior to LakePharma, he oversaw all discovery research functions both as Vice President of Protein Sciences at Surrozen, and previously, as Vice President of Research at Sutro Biopharma, Inc. We continue to serve our customers who are developing therapeutics, vaccines, and diagnostics through our primary products, she tells me. But, if you take the genes for spider silk and you put them in yeast, you can produce spider silk at large scale. She earned her Ph.D. in organic chemistry from the University of Houston and her M.Sc. Sato AK, Bitten ER, Senear DF, Alexander Ross JB, Rousslang KW.J Fluoresc. Electronic Drop Sensing In Microfluidic Devices: Automated Operation of a Nanoliter Viscometer Lab On A Chip 6: 744 -751(2006), Srivastava N., Burns M.A. The DNA-encoded nucleosome organization of a eukaryotic genome. The right antibody pair could be included in a test to determine is a person has Covid-19 or not, says Sato. Crispr, the gene-editing technology whose inventors won a Nobel Prize last year, has received far more attention, but the rise of gene synthesis promises to be an equally powerful development. Stafford RL, Zimmerman ES, Hallam TJ, Sato AK. GEN Edge: In terms of meeting the sustainable development challenges facing humanity, can you discuss what impact you hope your work will have? I think women are more likely to have this self-doubt. Emily Leproust. What was once taboo to discuss and was formerly rele TED, How DNA synthesis is powering the fourth manufacturing revolution - SynBioBeta Podcast, with Emily Leproust, "Towards practical, high-capacity, low-maintenance information storage in synthesized DNA", "BIO Announces 2020 BIO IMPACT Award Winners", Sitting down with Emily Leproust, CEO, Twist Bioscience Drug Discovery World, Asking All the Right Questions: Emily Leproust (01), Top Global Thinker University of Houston, "Strengthening Global Systems to Prevent and Respond to High-Consequence Biological Threats", https://en.wikipedia.org/w/index.php?title=Emily_Leproust&oldid=1097337241. Emily Leproust CEO Twist Bioscience December 20, 2021 4 min read In this article, Emily Leproust, Twist Bioscience CEO, reflects on the resilience of science and the achievements that give her hope for a brighter future. "We're. But technical advances in the last few years allowed the vaccine developers to synthesize much longer pieces of DNA and RNA at much lower cost, more rapidly. Like many technologies in their infancy, gene synthesis (along with the field it has enabled, synthetic biology) has sparked a good deal of speculation and start-up activity. Our customers are very happy, and we are making a big impact on the world. Writing DNA - Emily Leproust, CEO of Twist Bioscience - YouTube 0:00 / 18:47 Writing DNA - Emily Leproust, CEO of Twist Bioscience 23,542 views Dec 9, 2016 310 Dislike Share Save Hello. J Biol Chem. Washington, D.C. (September 17, 2020) - The Biotechnology Innovation Organization (BIO) announced Dr. Pramod Chaudhari, Executive Chairman of Praj Industries Limited, as the winner of the 2020 George Washington Carver Award for Innovation in Industrial Biotechnology and Agriculture and Dr. Emily Leproust, CEO and Co-Founder of Twist Bioscience, as the winner of the 2020 Rosalind Franklin . 2014 Oct 27;54(10):3020-32. doi: 10.1021/ci500362s. Prior to Twist Bioscience, he served as Chief Scientific Officer of LakePharma, leading the California Antibody Center, which discovers novel antibody therapeutics for its clients. The gift of feedback. Leproust earned her PhD in Organic Chemistry from University of Houston and her MSc in Industrial Chemistry from the Lyon School of Industrial Chemistry in her native France. 2020 Aug 1 : tbaa016. Leproust: Our platform makes DNA from scratch. I think what were just scratching the surface of is, can we program biology to do what chemists have traditionally done, he says. The company was represented by Leproust at a March 2021 tabletop exercise at the Munich Security Conference simulating an outbreak of weaponized monkeypox.[3]. Targeted genome enrichment for efficient purification of endosymbiont DNA from host DNA. This miniaturization reduces reaction volumes by a factor of 1,000,000 while increasing throughput by a factor of 1,000, enabling the synthesis of 9,600 genes on a single silicon chip at full scale. After that, I went to law school at UC Berkeley and then to work at Morrison & Foerster. Yiren Lu is a writer and software engineer based in New York. She last wrote for the magazine about start-ups trying to fix virtual meetings. Jobs Number of Current Jobs 2 Number of Past Jobs 1 Emily Leproust has 2 current jobs as Chief Executive Officer at Twist Bioscience and Investment Committee at NFX Bio. Katherine A. Stueland received an undergraduate degree from Miami University. If even a small percentage of these efforts succeed, they could lead to trillion-dollar markets. first released the genomic sequence of SARS-CoV-2 to public databases in January 2020, the two pharmaceutical companies were able to synthesize the DNA that corresponds to a particular antigen on the virus, called the spike protein. In 2020, the Biotechnology Innovation Organization (BIO) presented her with the Rosalind Franklin Award for Leadership. I was a senior research associate for CooperVision, where I developed a new contact lens material that was eventually manufactured and sold to the public. She earned her Ph.D. in Organic Chemistry from University of Houston and her M.Sc. How is this pillar of the booming synthetic biology industry weathering the Covid-19 crisis? General Counsel and Chief Ethics and Compliance Officer. J Biol Chem. Neoplasia. For synthetic biology, the next frontier is to go where even nature hasnt gone. The last thing you need is grit. She serves on the Board of Directors of CM Life Sciences and is a. Ginkgo is a platform company instead of producing end products for itself, it engineers cells for its clients. We had vaccine prototypes within weeks and shots in arms within the year. Im the founder of SynBioBeta, and some of the companies that I write aboutincluding Twist Bioscienceare sponsors of the SynBioBeta conference and weekly digest. As an early pioneer in the high-throughput synthesis and sequencing of DNA, Dr. Leproust is disrupting markets to enable the exponential growth of DNA-based applications including chemicals/materials, diagnostics, therapeutics, food and digital data storage. Targeted Drug Delivery with an Integrin-Binding Knottin-Fc-MMAF Conjugate Produced by Cell-Free Protein Synthesis. That is one of the dangers of having a company that grows quickly. Prior to Twist Bioscience, she served as Vice President, Head of Human Resources at QIAGEN, where she oversaw 50 human resources professionals supporting 4,000 employees through mergers and acquisitions, restructurings and other pivotal corporate transactions. PubMed PMID: 27197305. It would have been challenging for researchers to synthesize a DNA sequence long enough to encode the full spike protein. "Soo Boon is an early mover and leverages her experience and insight to develop and act on conviction Discovery of human antibodies against the C5aR target using phage display technology. If you can draw a molecule on a piece of paper, can we engineer an organism to produce that molecule, even if its something that nature has never seen before? Crispr, the gene-editing technology whose inventors won a Nobel Prize last year, Ginkgo Bioworks, a cell-engineering company that went public to much fanfare in September. Twist has enjoyed rapid revenue growth over the past few years, which Leproust attributes to simultaneous improvement not only of the product but also of the customer experience, from the website to customer support. This article about a chief executive from the United States is a stub. PubMed PMID: 11934284. Senior Vice President, Business Development for Data Storage. Sato A.K. Frayser M, Sato AK, Xu L, Stern LJ. Before the pandemic hit, Twist saw its stock price nearly triple since its IPO in 2018. Chief ESG Officer, Senior Vice President of Corporate Affairs. After a few days, the DNA is delivered to your laboratory door. If I want a boat, and tell my employee exactly the color, shape, and material of that boat, I will get that boat. The company harnesses synthetic biology, providing tools to manufacture insulin from yeast, to tackle malaria, [2] produce spider silk at scale [3] or store information on DNA. PMID: 34554826. An industrial chemist with a PhD in bioscience, Leproust and her team are reimagining industrial processes using nature's most powerful mechanisms. Dr. Leproust designed and developed multiple commercial synthesis platforms to streamline microarray manufacturing and fabrication. Picosecond pump-probe interferometric measurement of optical nonlinearities in channel waveguides. As interim CFO of Numonyx,he was responsible for coordination of the merger between ST Microelectronics and the IntelFlash Memory divisions as well as the financing to support the $2B revenue company. TMOc, and lab automation upstart Opentrons. The availability to synthesize DNA reliably and at low cost is poised to not only disrupt numerous markets, including chemicals, materials, diagnostics, therapeutics, and food, but also significantly improve the sustainability profile of manufacturing. Tom Z Yuan, Ana G Lujan Hernandez, Erica Keane, Qiang Liu, Fumiko Axelrod, Shweta Kailasan, Madeleine Noonan-Shueh, M Javad Aman, Aaron K Sato, Yasmina N Abdiche. Engineering toward a bacterial "endoplasmic reticulum" for the rapid expression of immunoglobulin proteins. Solution hybrid selection with ultra-long oligonucleotides for massively parallel targeted sequencing. Basically, this allows us to make a lot of antibody clones as part of a workflow. My grandmother used to say, Fear doesnt make the danger go away. It is important to learn to ignore a voice that tells you that you cant do something and just go for it. For example, CaS-9, the cutting enzyme used in Crispr, was originally a defense that bacteria evolved to fight off viruses. emily leproust husband. In 2020, BIO presented her with the Rosalind Franklin Award for Leadership. 2015 May-Jun;31(3):823-31. doi: 10.1002/btpr.2082. Xu Y, Jiang G, Tran C, Li X, Heibeck TH, Masikat MR, Cai Q, Steiner AR, Sato AK, Hallam TJ, Yin G. Org. Rapid discovery of diverse neutralizing SARS-CoV-2 antibodies from large-scale synthetic phage libraries. GEN Edge: Tell us a little bit about Twists DNA synthesis platform and how it is enabling advancements across multiple industries? Process Res. in Chemistry from Peking University in Beijing, China. Huang L, Sato AK, Sachdeva M, Fleming T, Townsend S, Dransfield DT. Policy on Unsolicited Submissions of Information. We dont need it to be growing on a plate. Mr. Hellmold joined Twist in October 2021, bringing more than 25 years of industry experience in product, technology as well as business development roles in semiconductor memory and data storage. Using synthetic biology, the chemicals currently being made from oil could be made from biomass. This has happened more with women than with men. Twist Bioscience, the company that Leproust and the Bills founded, currently synthesizes the longest DNA snippets in the industry, up to 300 base pairs. 1999 Dec 21;96(26):15050-5. Gnirke A, Melnikov A, Maguire J, Rogov P, LeProust EM, Brockman W, Fennell T, Giannoukos G, Fisher S, Russ C, Gabriel S. Solution hybrid selection with ultra-long oligonucleotides for massively parallel targeted sequencing. Development of mammalian serum albumin affinity purification media by peptide phage display. Erin earned her J.D. Epub 2014 Dec 16. Before joining Twist, Mr. Hellmold was Vice President, Corporate Strategy and Business Development for Strategic Initiatives at Western Digital. A synthetic bispecific antibody capable of neutralizing SARS-CoV-2 Delta and Omicron. If you type print hello world, you expect the computer to return hello world. If you synthesize a DNA sequence, ACTCAG, and put it in a cell, you might be able to predict with some confidence what comes out of the cell, but you never really know. And further advances in machine learning and computer modeling will only multiply the possibilities. Everything that is a plastic today could be replaced by protein. Prior to Enzymatics, Paddy held positions with increasing commercial focus, including Director of Business Development at Agilent Technologies, Director of Product Development for Beckman Coulter Molecular Diagnostics, and multiple technical roles in product development within Invitrogen and GE Healthcare/Amersham International. Foreign Policy named her one of their 100 Leading Global Thinkers and Fast Company named her one of the Most Creative People in Business. 2009 Aug 7;5(2):168-77. doi: 10.1016/j.stem.2009.05.019. Connect on AIChE Engage year Twist Bioscience. But antibodies can also play a diagnostic role. Dr. Chen conceived and implemented a new product line for NGS that includes synthetic controls for SARS-CoV-2 and other infectious diseases, developed gene synthesis and NGS target enrichment biochemistries, workflow, reagent kits, and infrastructure, and built the companys prototype DNA synthesizer in collaboration with hardware, software, and silicon engineers, which later became a production-scale machine, serving as Twists foundation technology. 1994 Jun;4(2):195-201. doi: 10.1007/BF01881888. The company has developed a semiconductor-based technology that allows for DNA to be synthesized on a 10,000-well silicon chip [8] . 2022.01.04.474803;doi:https://doi.org/10.1101/2022.01.04.474803. So what does this look like in practice? But, as you go up the chain, the representation of men increases. Leproust and several other former Agilent employees who joined her at Twistincluding Twist's Senior Director of Chemistry and Molecular Biology Siyuan Chen and Twist's former Chief Financial. Can we turn DNA into circuits that enable cells to act as living computers? Mr. Thorburn is a seasoned technology executive with more than 30 years of finance andoperating experience in both private and public technology companies. Why you should listen As cofounder and CEO of Twist Bioscience, Emily Leproust drives new applications for DNA writing to address the global challenges of public health, therapeutic development, food insecurity and sustainability. PMID: 33706686; PMCID: PMC7971233. Yuan TZ, Garg P, Wang L, Willis JR, Kwan E, Hernandez AGL, Tuscano E, Sever EN, Keane E, Soto C, Mucker EM, Fouch ME, Davidson E, Doranz BJ, Kailasan S, Aman MJ, Li H, Hooper JW, Saphire EO, Crowe JE, Liu Q, Axelrod F, Sato AK. With her illustrious work and growing company, Dr. Leproust is one of the top female executives in the world. Dr. Chen is the author of numerous peer-reviewed papers and issued patents in the field of oligonucleotide synthesis and application of synthetic oligonucleotides. As a customer, you can visit the Twist website, upload a spreadsheet with the DNA sequence that you want, select a quantity and pay for it with a credit card. A Nanoliter Viscometer for analyzing blood plasma and other liquid samples Analytical Chemistry 77(2): 383-392, 2005, Pal R., Yang M., Lin R., Johnson B.N., Srivastava N., Razzacki Z., et al An integrated microfluidic device for Case Update - Agilent v. Twist Litigatio n On January 29, 2019, Twist Bioscience and Emily Leproust filed a demurrer and motion to strike Agilent's second amended complaint, challenging each of Agilent's legal claims. We stayed focused through good and bad times, and here we are. And now more than ever, she says synthetic biology needs to deliver. My parents are entrepreneurs in real estate. She grew up in France and completed a Ph.D. in organic chemistry at the. Goldman N, Bertone P, Chen S, Dessimoz C, LeProust EM, Sipos B, Birney E. Towards practical, high-capacity, low-maintenance information storage in synthesized DNA. Protein Eng Des Sel. Digital RNA allelotyping reveals tissue-specific and allele-specific gene expression in human. Temporal and spatial profile of brain diffusion-weighted MRI after cardiac arrest. The same goes for semiconductors: As small as one of Twists 10-picoliter wells might seem, Leproust points out that from the perspective of the 21st-century semiconductor industry, its a Grand Canyon, almost like being in the Stone Age. Already, the company is experimenting with chips whose wells are more than 300 times smaller, with diameters of 150 nanometers. Nimisha joined Twist in March 2014 and was instrumental in automating processes and procedures to fuel the growth of Twist into a leading global manufacturer of synthetic DNA. GEN Edge: Can you discuss your background and what led you to found Twist Bioscience in 2013? 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